Gochnatia polymorpha (Less.) Cabrera

Nota de alcance

PARTE UTILIZADA= Used part: Hojas y flores. 

ACCIÓN FARMACOLÓGICA= Pharmacological action: Anticatarral, pectoral. 

COMPOSICIÓN QUÍMICA= Chemical composition: De las partes aéreas y raíces, se han aislado los siguientes sesquiterpenos: 1,2-deshidro-I,14-dihidro-12,15-dioxobisaboleno, 1,2-deshidro-1,14-dihidro-15oxobisaboleno, costunólido, deshidrocostuslactona, gochnatiólido A, 10-alfa-H,1-10 deshidro, 2-alfa-hidroxi-10-desoxigochnatiólido A, 10-alfa-H,1 1-1 1`13-13` tetrahidro, 10-desoxigochnatiólido A, 10-alfa-H,11-11`-13-13`tetrahidro, 10-desoxigochnatiólido A, 10-alfa-H,8-hidroxi-10-desoxigochnatiólido A, 8-hidroxigochnatiolido A, nuciferal, 15-oxonuciferol y oxonuciferol (Bohlmann et al. 1986). 

ZONA GEOGRÁFICA= Geografical zone: SE. de Brasil, Paraguay, Uruguay, E. de Argentina. 

Nota de alcance

ÚLTIMOS AVANCES EN LA QUÍMICA Y ACTIVIDADES BACTERIOLÓGICAS EN LAS PLANTAS MEDICINALES= Medicinal plants, last advances on chemistry and bacteria activities on the medicinal herbs

1) The aqueous and ethanol extracts from the leaves of Gochnatia polymorpha and further fractions obtained from the latter extract using solvents with increasing polarity, including its aqueous residue and the amino acid, 4-hydroxy-N-methyl-proline were investigated by carrageenin-induced pedal oedema formation.  It was shown that the aqueous and ethanol extracts and the ethyl acetate fraction demonstrated significant antiinflammatory activity.  The chemical investigation of the latter fraction revealed the presence of caffeic acid, chlorogenic acid, 3-0-methylquercetin, hyperosid and rutin.  The amino acid 4-hydroxy-N-methyl-proline, a nonprotein amino acid that has not been reported before in the Asteraceae was isolated as a major compound and identified by spectroscopic methods.

Nota bibliográfica

1) TOURSARKISSIAN, Martín. Plantas medicinales de Argentina : sus nombres botánicos, vulgares, usos y distribución geográfica. Buenos Aires : Hemisferio Sur, 1980 .

2) 270 (doscientos setenta) plantas medicinales iberoamericanas. Santiago de Bogotá : CYTED-SECAB, 1995.

3) MOREIRA, A. S.; SPITZER, V; SCHAPOVAL, E. E.; SCHENKEL, E. P. Antiinflammatory activity of extracts and fractions from the leaves of Gochnatia polymorpha. Phytotherapy Research : PTR. 2000, Vol.14, nº8, p.638-40.

Gochnatia polymorpha (Less.) Cabrera
Término aceptado: 23-Ago-2007