Potentilla anserina L.

Nota de alcance

PARTE UTILIZADA= Used part: Sumidades flridas. 

ACCIÓN FARMACOLÓGICA= Pharmacological action: antidiarreico, cicatrizante, espasmolítico. 

POSOLOGÍA= Posology: 4 g/día de planta o preparacion equivalente. 

COMPOSICIÓN QUÍMICA= Chemical composition: Taninos (2 % calculado com ácido gálico), tormentósido, flavonoides, antocianósidos, fitosterol. 

ZONA GEOGRÁFICA= Geografical zone: Hemisferio Norte, Argentina. 

Nota de alcance

ÚLTIMOS AVANCES EN LA QUÍMICA Y ACTIVIDADES BACTERIOLÓGICAS EN LAS PLANTAS MEDICINALES= Medicinal plants, last advances on chemistry and bacteria activities on the medicinal herbs

The polysaccharide (PAP) from Potentilla anserina was evaluated for modulating effects by using mouse peritoneal macrophage and the immunosuppressed-model cyclophosphamide-induced.  Phagocytotic and mononuclear phagocytic system function assays showed that PAP stimulated the phagocytosis of phagocyte.  Splenocyte proliferation assay showed that PAP acted the effect combining Con A or LPS in splenocyte proliferation.  The parameters detected showed that PAP increased thymus and spleen indexes, the levels of LDH and ACP in the spleen, and IL-10and IFN-g in serum in immunosuppressed mice.  The results suggest that PAP is involved in immunomodulatory effects leading to the exploration for PAP as a potential immunostimulant.

2) The Tibetan herb Potentilla anserina L. has been widely used in China for many thousands of years to treat hepatitis-B.  Bioassay-guided fractionation of the ethanol ext. of the rhizomes led to the isolation of a triterpenoid saponin (TS) that was detd. to be 2a,3b,19a-trihydroxyurs-12-en-28-oic acid b-D-glucopyranosyl ester.  Using models of HBV infection, this compd. was evaluated for its effect on HBV antigene expression in the 2.2.15 cell line in vitro and anti-hepatitis B virus (HBV) activities in Peking ducklings in vivo.  Results showed that it could decrease the expression levels of HBsAg, HBeAg and HBVDNA in the 2.2.15 cell culture and the inhibitory effect was not due to the cytotoxicity of the triterpenoid saponin.  The antiviral study in vivo on Peking ducklings also demonstrated that this compd. inhibits duck hepatitis B virus (DHBV) DNA replication.

Nota de alcance

Patente extraída del Chemical Abstracts= Patent extrated from the Database Chemical Abstracts

 Formulation based on micronized zeolite, green tea extract, and genistein as a therapeutic agent for reduction of body weight and cellulite.      Lelas, Antonio; Cepanec, Ivica.  (Novatech Istrazivanje D.O.O., Croatia).    PCT Int. Appl.  (2010),     32pp.  CODEN: PIXXD2  WO  2010097643  A1  20100902  Designated States W: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR.  Designated States RW: AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IS, IT, LU, MC, MT, NL, NO, PT, SE, TR, BF, BJ, CF, CG, CI, CM, GA, ML, MR, NE, SN, TD, TG.  Patent  written in English.    Application: WO  2009-HR5  20090224.  Priority: WO  2009-HR5  20090224.  CAN 153:343678    AN 2010:1100573    CAPLUS   (Copyright (C) 2011 ACS on SciFinder (R))  

The invention relates to a pharmaceutical formulation based on variable portions of: (i) micronized zeolite (MZ) of general formula: (Men+)x/n[(AlO)x(SiO2)y].mH20 (Me = Na, K, Mg, Ca; whereas ratio of Si to Al y:x is 6:1 to 1:1; no. of cryst. water m = 0-20), which is characterized by particles size < 5 mm; in concns. from 1-50%, most preferably from 3-30%; (ii) green tea ext. contg. at least 30% of epigallocatechin gallate (EGCG) and 5% of caffeine; in concns. from 0.1-90%, most preferably from 20-90%; (iii) genistein; in concns. from 0.05-20%, most preferably from 1-10%; and (iv) one or more excipients which yield in desired pharmaceutical or cosmetic form: tablets, capsules, ointments, creams, gels, lotions, shampoos, powders, liq. powders, syrups, suspensions, and therapeutic patches; in concns. from 1-98.85%, most preferably from 10-75%; which is useful for highly effective redn. of body wt. and cellulite.  Thus, women using a hydrophilic (O/W) cream contg. 2% of micronized zeolite clinoptilolite (MZ), 2% of green tea ext. and 0.25% genistein reported significant redn. of intensity of cellulite appearance in comparison to women which used a control cream of the same compn. but without MZ.

Nota bibliográfica

1) Fitoterapia: vademecum de prescripción. 4ª. ed. Barcelona: Masson, 2003, p.126.

2) CHEN, Jiong-Ran, et al. Immunomodulatory activity in vitro and in vivo of polysaccharide from Potentilla anserina. Fitoterapia. 2010, vol.81, nº8, p.1117-1124.
3) ZHAO, Y.-L., et al.   Anti-hepatitis B virus activities of triterpenoid saponin compound from Potentilla anserine L. Phytomedicine. 2008, vol.15, nº4, p.253-258.

Potentilla anserina L.
Término aceptado: 23-Nov-2010