Teucrium chamaedrys L.

Nota de alcance

PARTE UTILIZADA= Used part: Sumidades floridas, planta en flor seca.

ACCIÓN FARMACOLÓGICA= Pharmacological action:
Propiedades tónicas-eupépticas, carminativas, astringente, útil en diarreas, actividad antimicrobiana, influencia en actividad ovárica, puede producir reducción de los estrógenos libres.

EFECTOS ADVERSOS Y/O TOXICOLOGÍA= Adverse effects and toxicology:
En altas dosis puede producir hepatotoxicidad, dolores abdominales, subictericia, hepatitis.

POSOLOGÍA= Used part:
Se prepara una tintura en base a un macerado de 10 g de planta en flor en 100 g de alcohol de 75 grados durante 10 días. Se prescribe a razón de 10 gotas en medio vaso de agua, antes del almuerzo y cena.

COMPOSICIÓN QUÍMICA= Chemical composition: Teucrinas A, B, E, F, G, isoteuflidin, 6-epinteclina A, teuchamaedrinas B y C, chamaedróxido, teucrócido, apigenina, apigatrina, apiganina-7-rutinósido, cirsiliol, cirsimaritina, diosmetina, hipolaetina, isoquersitina, isoescultelareina, vicenina 2, estigmasterol, beta-sitosterol, triterpenos, ácido ursílico, teurcriósido(lignano), colina, aceite esencial (0.06%), taninos, estaquioca (azúcar).

ZONA GEOGRÁFICA= Geografical zone:

Nota de alcance

DIVERSIDAD GENÉTICA Y MEJORAMIENTO DE PLANTAS MEDICINALES= Medicinal plants and improvement of medicinal herbs:
Pharmacol. active ingredients in plants can cause significant morbidity through their increasingly common use in herbal
alternative medicines and dietary supplements. Monitoring consumer products for the presence of toxic plants is
encumbered by the lack of rapid and specific assays. To create a sensitive, reliable, fast, and broad-spectrum assay for medicinal or toxic plant species, the authors tested multiplexed ligation-dependent probe amplification (MLPA), which requires partial genomic DNA sequences from species of plants that are not well represented in currently available genetic databases. Genomic DNA was obtained from 21 species of medicinal and/or toxic plants. The PCR products were amplified from these plants and cloned for sequencing. The MLPA method was successful with DNA samples from many different species. The use of a microarray to facilitate screening of potentially thousands of plants in a single assay also was successful. The combination of the specificity of the MLPA assay with the broad-scale capabilities of microarray technol. should make this an esp. useful tool in screening in foods and com. herbal prepns. to identify the plant compds. actually present. Other applications could potentially extend to the identification of any plant species in samples for academic botanical studies and for biodefense and forensics applications.

Nota de alcance

ÚLTIMOS AVANCES EN LA QUÍMICA Y ACTIVIDADES BACTERIOLÓGICAS EN LAS PLANTAS MEDICINALES= Medicinal plants, last advances on chemistry and bacteria activities on the medicinal herbs

1) The essential oil obtained by hydrodistn. from Teucrium chamaedrys L. (Lamiaceae) from Turkey was analyzed by (GC) and (GC/MS). Thirty six components in aerial parts of T. chamaedrys were identified representing (90.8%) of the oils. Main constituents of the oil were found as germacrene D (32.1%), b-caryophyllene (14.2%), d-cadinene (13.1%),
bicyclogermacrene (6.7%) and b-farnesene (4.3%). The results were discussed with the genus pattern in means of
medicinal purpose and natural products.

2) Scutellaria lateriflora, commonly known as skullcap, is used as an ingredient in numerous herbal products. However, it has been occasionally adulterated/contaminated with Teucrium canadense and T. chamaedrys, commonly known as
germander, which contain hepatotoxic diterpenes. Due to the morphol. similarities between the two genera, anal.
methodologies to distinguish authentic S. lateriflora from the Teucrium species are needed to ensure public safety. In
this study, a direct-injection electrospray ionization/MS method was used to generate spectral fingerprints of exts. from
21 skullcap and germander samples at a rate of 90 s/sample. MS fingerprints were analyzed by principal component
anal. The newly developed method offers a rapid and easy way to differentiate between skullcap and germander

3) Three new nor-neo-clerodane diterpenes, named chamaedryoside A (1), B (2) and C (3), have been isolated from the org. exts. of Teucrium chamaedrys and their structural characterization has been accomplished by 1H and 13C-NMR spectra, and DEPT, by COSY, TOCSY, HSQC, HSQC-TOSCY and HMBC expts., as well as by ESI-MS/MS techniques.
The stereostructures have been elucidated by NOESY and computational calcns.

Nota de alcance

Patente extraída del Chemical Abstracts= Patent extrated from the Database Chemical Abstracts

Methods and therapeutic compositions comprising plant extracts for the treatment of cancer
By: Cyr, Benoit
Assignee: Biopharmacopae Design International Inc., Can.
Patent Information: Apr 20, 2006, WO 2006039807, A1
Application: Oct 17, 2005, WO 2005-CA1576
Priority: Oct 15, 2004, US 2004-619393P, Oct 17, 2005, WO 2005-CA1576, Aug 30, 2002, CA 2002-2400936, Sep 02, 2003, WO 2003-CA1284,
Oct 06, 2005, US 2005-526387, Mar 07, 2008, US 2008-577292
Source: PCT Int. Appl., 165 pp., Patent, 2006, CODEN: PIXXD2
Accession Number: 2006:365429, CAN 144:381990, CAPLUS
Language: English

A method of treating cancer by targeting two proteases, MMP-9 and cathepsin B is provided. Therapeutic compns.
comprising one or more plant exts. that inhibit MMP-9 and/or cathepsin B, which are capable of inhibiting neoplastic
and/or endothelial cell migration, tumor growth, tumor-induced angiogenesis and/or metastasis are also provided. The
therapeutic compns. of the invention can be used in the treatment of cancer, and, methods of inhibiting tumor growth,
tumor metastasis, and/or tumor-induced angiogenesis using the therapeutic compns. alone or in combination with an
anti-cancer agent are, therefore, also provided.

Nota bibliográfica

1) ALONSO, Jorge R. Tratado de fitomedicina : bases clínicas y farmacológicas. Buenos Aires : ISIS, 1998, p. 321.

2) BAGCI, Eyup, et al. Composition of the essential oil of Teucrium chamaedrys L. (Lamiaceae) from Turkey. Journal of Medicinal Plants Research, vol. 4, nº23, p.2588-2590.

3) CHEN, Pei; LIN, Long-Ze; HARNLY, James M. Mass spectroscopic fingerprinting method for differentiation between Scutellaria lateriflora and the germander (Teucrium canadense and T. chamaedrys) species.Journal of AOAC International. 2010, vol. 93, nº 4, p. 1148-1154.

4) FIORENTINO, Antonio, et al. Structure determination of chamaedryosides A-C, three novel nor-neo-clerodane glucosides from Teucrium chamaedrys, by NMR spectroscopy. Magnetic Resonance in Chemistry. 2009, vol. 47, nº 11, p. 1007-1012.
5) BARTHELSON, Roger A., et al. Development of a comprehensive detection method for medicinal and toxic plant species. American Journal of Botany. 2006, vol. 93, nº 4, p. 566-574.

Teucrium chamaedrys L.
Término aceptado: 24-Abr-2012