PARTE UTILIZADA= Used part: Corteza. 

ACCIÓN FARMACOLÓGICA= Pharmacological action: Antifebril. 

COMPOSICIÓN QUÍMICA= Chemical composition: Eleven known indole alkaloids: vallesine, aspidospermine, 11-methoxydichotine, apparicine, tubotaïwine, vincadifformine, condylocarpine, (-)-rhazinilam, aspidospermatine, haplocidine, and 18-oxohaplocidine, have been isolated from leaves and stems of Vallesia glabra (Cav.) Link. (Apocynaceae) from Bolivia. Analysis of 2 D NMR spectra complete previous 'H and I3C data for vallesine, aspidospermine, and 11-methoxydichotine. 

ZONA GEOGRÁFICA= Geografical zone: Bolivia y N. de Argentina. 

ÚLTIMOS AVANCES EN LA QUÍMICA Y ACTIVIDADES BACTERIOLÓGICAS EN LAS PLANTAS MEDICINALES= Medicinal plants, last advances on chemistry and bacteria activities on the medicinal herbs

1) Eleven known indole alkaloids: vallesine, aspidospermine, 11-methoxydichotine, apparicine, tubotaiwine, vincadifformine, condylocarpine, (-)-rhazinilam, aspidospermatine, haplocidine, and 18-oxohaplocidine, were isolated from leaves and stems of V. glabra from Bolivia.  Anal. of 2 D NMR spectra completed previous 1H and 13C data for vallesine, aspidospermine, and 11-methoxydichotine.

2) Seventy-seven plant extracts (corresponding to 62 different species) traditionally used by the Isoceno-Guarani, a native community living in the Bolivian Chaco, were screened for antimalarial activity in vitro on Plasmodium falciparum chloroquine sensitive strain (F32), and on ferriprotoporphyrin (FP) IX biocrystallisation inhibition test (FBIT).  Among these extracts, seven displayed strong in vitro antimalarial activity, and 25 were active in the FBIT test.  Positive results on both tests were recorded for six extracts: Argemone subfusiformis aerial part, Aspidosperma quebracho-blanco bark, Castela coccinea leaves and bark, Solanum argentinum leaves and Vallesia glabra bark.  Results are discussed in relation with Isoceno-Guarani traditional medicine.  Further studies to be undertaken in relation with these results are also highlighted.

1) TOURSARKISSIAN, Martín. Plantas medicinales de Argentina : sus nombres botánicos, vulgares, usos y distribución geográfica. Buenos Aires : Hemisferio Sur, 1980, p.8.

2) ZECHES, M., et al.  Alkaloids from Leaves and Stems Of Vallesia glabra. Planta Medica [en línea]. 1995, vol. 61 ^Consulta: 04 Diciembre 2008].
Disponible en: http://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_6/b_fdi_35-36/41688.pdf

3) ZECHES, M.,et al. Alkaloids from leaves and stems of Vallesia glabra. Planta Medica . 1995, vol.61, nº1, p.89-91.
 
4) BOURDY, G., et al. A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part VI. Evaluation of the antimalarial activity of plants used by Isoceno-Guarani Indians. Journal of ethnopharmacology . 2004, vol.93, nº2-3, p.269-77.