Patente

2. Cosmetic method for increasing collagen expression in skin comprising topically applying an extract of Quassia amara
By Cenizo, Valerie; Andre, Valerie
From U.S. Pat. Appl. Publ. (2015), US 20150056310 A1 20150226, Language: English, Database: CAPLUS

The present invention relates to a cosmetic method for increasing collagen gene and/or protein expression comprising topically applying an effective amt. of an ext. of the plant Quassia amara onto skin and/or mucous membranes. The present invention relates as well to a cosmetic method comprising topically applying an effective amt. of such an ext. for increasing the firmness of skin and/or mucous membranes
of an individual in need thereof. The present invention also relates to a method of cosmetic care comprising topically applying a compn. comprising an effective amt. of the ext. of Q. amara onto skin and/or mucous membranes, for increasing the collagen gene and/or protein expression. Thus, cosmetic and/or dermatol. ingredient contg. the Q. amara wood ext. comprised (in wt%): Q. amara wood ext. 5, pentylene glycol 5, butylene glycol 20, keltrol 0.5, water q.s. 100.

Uses: local pain, fever, malaia, diarrhea, stomach infection, intestine, gastrointestinal problems.                                                 

Origin: Belize, Brazil, Colombia, Costa Rica, French Guiana, Guatemala, Guyana, Honduras, Mexico, Nicaragua, Panama, Suriname, United States, Venezuela.                 

Root: Infusion used to reduce malarial fever (overdose believed to cause paralysis).

Bark: Bark is boiled and the water drunk as an anti-diarrheal, as an anti-dysenteric, and as an antimalarial, by the Guyana Patamona. Macerated inner bark is boiled, and the water drunk to treat colds, by the Guyana Patamona.

Bark and Leaf: Bark and leaves are boiled, and the water drunk as an anti-pyretic, by the Guyana Patamona.

Stem: Wood chips are decocted in lotions for persistent venereal ulcers. Infusion of wood and fresh roots is used for refractory fevers, tonic, aperitive and febrifuge. In French Guiana an alcohol extract is called "quassine". Piece of wood in water, gin, vermouth or cognac is drunk as a pyretic for fever, e.g., malarial fever. Infusion is a good tonic for the stomach and intestines. Stem is also used in remedies for diseases of the spleen, liver (cirrhosis), and urinary tract. Bark used as a blood purifier and for treating weak eyes of alcoholics. Bark macerated in rum for a vermifuge. Bark is mixed with the macerated stem of Tinospora crispa in rum, cognac or absinthe for a beverage employed against diabetes and albuminuria. Chipped, soaked in wine or water, and the extract used to restore appetite and as a tonic to reduce blood sugar levels. In Surinam, stem is employed to make bitters for reducing a fever.

Wood: Used for treatment of biliousness, malaria an sores in NW Guyana.

Stem and Leaf: Decoction of bark and leaves used as a wash to rid skin of external parasites such as agouti lice. Infusion of bark and leaves for a febrifuge, bitter tonic and vermifuge; cholagogue. Boiled for a liquid bath to treat measles and smallpox in Guyana.

Leaf: Crushed leaves placed on body reputedly act as a mosquito repellent. Used in treatment of fevers in NW Guyana.

Leaf, Flower and Root: Infusion for a febrifuge in French Guiana. Flower: Infusion is drunk to alleviate a heavy feeling in stomach.

Seed: Used for malaria in NW Guyana.

PARTE UTILIZADA= Used part: Leño.

ACCIÓN FARMACOLÓGICA= Pharmacological action: Tónico amargo para estimular el apetito y como digestivo.

COMPOSICIÓN QUÍMICA= Chemical composition: Leño, de 0,05% hasta mas del 0,2% de sustancias amargas pertenecientes al grupo de los cuasinoides (secotriterpenos), siendo las principales: cuasina (con un índice de amargo de 17 millones), neocuasina y 18-hidroxicuasina. Se han identificado también otros componentes, concretamente 3 alcaloides beta-carbonílicos.

ZONA GEOGRÁFICA= Geografical zone: Uruguay.

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Origen: Es nativo desde México hasta el norte de América del Sur inclusive el Amazonas y las Antillas.

Usos:
Baja la fiebre; expulsa cálculo del hígado y los riñones; antidiarreico y mejora los malestares del esttómago; contra la ameba; alivia los dolores de cabeza y el catarro; combate paludismo; previene el insomnio.

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Origen:
Se encuentra desde el sur de México hasta la Amazonía en alturas hasta de 950 m s.n.m. Especie nativa de bosques secos y húmedos en laderas con regular penetración de luz (MORTON, 1981).

Usos etnomédicos y modo de empleo:
En infusión o macerado se emplea como tónico amargo estimulante del apetito. Además, se considera eficaz para combatir la fiebre, cálculos del hígado y riñones, y contra la debilidad de tejidos en órganos digestivos. Se usa en casos de diarreas y malestares del estómago, es vermífugo y contrarresta las fiebres maláricas (OCAMPO & MAFFIOLI, 1987; MARTÍNEZ, 1992). Se le atribuyen propiedades amebicidas, antianémicas, antisépticas, aperitivas, febrífuga, pediculicidas, tónicas y vermífugas (MORTON, 1981; GUPTA, 1995).

1) Plantas medicinales y drogas vegetales para infusión y tisana : un manual de base científica para farmacéuticos y médicos / edición española a cargo de Salvador Cañigueral; Roser Vila; Max Wichtl . España : OEMF, 1998. p. 425.

2) Geraldini , Isanete, Journal of Ethnopharmacology v. 173, 2015 . -- p. 383-423

3) Quesada Hernàndez, Alonso/ Herbario nacional de Costa Rica. Costa Rica: Arena Trans Amèrica, 2008. - p. 61

4) Gupta, Mahabir P.; Santana, Ana Isabel; Espinosa, Alex/ Plantas medicinales de Panamá. sd: sd. - p. sd.