PARTE UTILIZADA= Used part: Planta entera. 

ACCIÓN FARMACOLÓGICA= Pharmacological action: Amargo, tónico, antifebril. 

COMPOSICIÓN QUÍMICA= Chemical composition: A new clerodane diterpene, 15-hydroxy-16-acetoxy-ent-clerod-3-en-18-oic acid (1), together with 3 known clerodane diterpenes (2-4) and 3 known flavones (5-7), were isolated from the aerial parts of B. gaudichaudiana. Their structures were elucidated on the basis of spectroscopic anal. Compds. 2, 3, and 5 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells. 

ZONA GEOGRÁFICA= Geografical zone: Brasil hasta Argentina (Misiones). 

ÚLTIMOS AVANCES EN LA QUÍMICA Y ACTIVIDADES BACTERIOLÓGICAS EN LAS PLANTAS MEDICINALES= Medicinal plants, last advances on chemistry and bacteria activities on the medicinal herbs

1) Three new ent-clerodane diterpenes (1-3) were isolated from the aerial parts of Baccharis gaudichaudiana, and their structures were elucidated as 15,16-epoxy-15a-methoxy-ent-clerod-3-en-18-oic acid (1), 13-epi-15,16-epoxy-15alpha-methoxy-ent-clerod-3-en-18-oic acid (2), and 7-oxo-16-hydroxy-ent-clerod-3-en-15-oic acid Me ester-18,19-olide (3), on the basis of spectroscopic data anal.  A known compd., 7-oxo-ent-clerod-3-en-15,16:18,19-diolide, was also identified.  Compds. 1 and 2 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC12D cells.

2) Three new labdane diterpenes, gaudichaudols A-C, a new clerodane diterpenoid, gaudichaudone , and the known clerodane, articulin acetate en isolated from the aerial parts of Baccharis gaudichaudiana, together with the known compds., apigenin, hispidulin, spathulenol, and ursolic acid.  Through the application of 1D- and 2D NMR spectroscopy, the structures of the above new diterpenoids were, in turn, elucidated as 15,16,18,19-tetrahydroxylabd-5-ene, 15-O-acetyl-16,18,19-trihydroxylabd-5-ene, 16-O-p-trans-coumaroyl-15,18,19-trihydroxylabd-5-ene, and 2beta-hydroxy-15,16-epoxycleroa-1(10),15,16-trien-18,19-olide.  The isolated compds. were evaluated in P-388 lymphocytic leukemia cells as well as a battery of human cancer cell lines.  Among the diterpenoids, gaudichaudol C , gaudichaudone , and articulin acetate exhibited significant cytotoxic activity against certain cancer cells.

1) TOURSARKISSIAN, Martín. Plantas medicinales de Argentina : sus nombres botánicos, vulgares, usos y distribución geográfica. Buenos Aires : Hemisferio Sur, 1980, p.26.

2) GUO, Yuanqiang, et. al. Clerodane diterpenoids and flavonoids with NGF-potentiating activity from the aerial parts of Baccharis gaudichaudiana. Chemical & Pharmaceutical Bulletin. 2007, vol.55, nº10, p.1532-1534.
 
3) GUO, Yuanqiang, et al. Bioactive ent-Clerodane Diterpenoids from the Aerial Parts of Baccharis gaudichaudiana. Journal of Natural Products . 2006, vol.69, nº2, p.274-276.
 
4) FULLAS, Fekadu, et al. Cytotoxic constituents of Baccharis gaudichaudiana. Journal of Natural Products. 1994, vol.57, nº6, p.801-807.