PARTE UTILIZADA= Used part: Extracto aquoso. 

ACCIÓN FARMACOLÓGICA= Pharmacological action: Antitumoral, antioxidante, prooxidante, anticancerigeno, patologías inmunológicas, psoriasis, artritis y artrosis.  

COMPOSICIÓN QUÍMICA= Chemical composition: Schottenol glucoside.

DIVERSIDAD GENÉTICA Y MEJORAMIENTO DE PLANTAS MEDICINALES= Medicinal plants and improvement of medicinal herbs

The ability of two plant-produced macrocyclic trichothecenes (baccharinoid B4 and roridin E) to induce callus growth of two trichothecene-producing Baccharis species (B. coridifolia and B. megapotamica) and two nontrichothecene-producing species (B. halimifolia and B. neglecta) was investigated. Roridin E had no effect in the induction of callus of B. coridifolia, a roridin-producing plant, but induced callus of nonroridin-producing plants (B. megapotamica, B. halimifolia, and B. neglecta). Baccharinoid B4 stimulated callus growth of B. megapotamica, a baccharinoid-producing plant, and inhibited growth of B. coridifolia, B. halimifolia, and B. neglecta callus tissues. The ability of roridin E to induce callus was most effective at concentrations of 10-8 and 10-6 M and when synergistically coupled with auxin, 2,4-dichlorophenoxyacetic acid (2,4-D). The ability of baccharinoid B4 to stimulate callus growth appeared to increase with increased concentration in the culture medium. Analysis of callus cultures grown in medium amended with roridin E showed that B4, roridin E, and 8β-hydroxyroridin E and verrucarols were formed in the tissues but not in the medium. The results of this study indicated that while the callus-inducing ability of roridin E seemed to be nonspecies-specific in nature, the ability of B4 to stimulate callus was a highly species-specific phenomena. Callus-inducing activity of roridin E may depend on the capacity of plant species to transform exogenous roridin E into baccharinoids or other macrocyclic trichothecene derivatives. © 1992 Springer-Verlag. 

ÚLTIMOS AVANCES EN LA QUÍMICA Y ACTIVIDADES BACTERIOLÓGICAS EN LAS PLANTAS MEDICINALES= Medicinal plants, last advances on chemistry and bacteria activities on the medicinal herbs

1) Four macrocyclic trichothecenes, roridin A, roridin E, verrucarin A and verrucarin J, produced by the hypocrealean epibiont of Baccharis coridifolia, were evaluated for their inhibitory activity against the arena-virus Junin (JUNV), the etiol. agent of Argentine hemorrhagic fever.  The trichothecenes achieved a dose-dependent inhibition of JUNV multiplication at concns. not affecting cell viability.  The 50% inhibitory concn. (IC50) values detd. by a virus yield inhibition assay were in the range 1.2-4.9 ng/mL.  The most active compd. was verrucarin J which reduced JUNV yield more than 2 log units and had a similar effect against the arenavirus Tacaribe.  The trichothecenes lacked virucidal effects on JUNV virions.  From time of addn. and removal expts., it can be concluded that verrucarin J inhibited a late stage in the replicative cycle of JUNV, after 5 h of adsorption.

2) The essential oil of Baccharis coridifolia D.C., obtained by hydrodistn. of the aerial part of female plants in flowering-fructification, was analyzed by GC (retention indexes) and GC/MS.  The anal. revealed the presence of 29 compds. (89.2% of the oil) of which isocaryophyllene (34.3%), beta-caryophyllene (10.8%), caryophyllene oxide (9.8%) and beta-selinene (8.2%) were the major components.

1) MONKS, N.R., et al. Anti-tumour screening of Brazilian plants. Pharmaceutical Biology. 2002, vol.40, nº8 , p.603-616.
 
2) DESMARCHELIER, C., et al. Antioxidant and prooxidant activities in aqueous extracts of Argentine plants. Pharmaceutical Biology. 1997, vol.35, nº2, p.116-120.
 
3) ARISAWA, M,. et al. Plant anticancer agents XXXVI. Schottenol glucoside from Baccharis coridifolia and Ipomopsis aggregata. Planta Medica. 1985, nº6, p.544-545.
 
4) KUTTI, J.O.; JARVIS, B.B. Growth hormone-like activities of macrocyclic trichothecenes in in vitro callus induction and growth of four Baccharis species. Journal of Plant Growth Regulation. 1992, vol.11, nº3, p.149-154.
 
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6) BAILAC, Pedro N., et al. Essential oil of female plants of Baccharis coridifolia De Candole.  Journal of Essential Oil Research. 2001, vol.13, nº1, p.23-24.