{"tema_id":"6876","string":"Agrimonia eupatoria L.","created":"2010-09-13 10:27:04","code":null,"notes":[{"@type":"Nota de alcance","@lang":"es","@value":"\u00daLTIMOS AVANCES EN LA QU\u00cdMICA Y ACTIVIDADES BACTERIOL\u00d3GICAS EN LAS PLANTAS MEDICINALES= Medicinal plants, last advances on chemistry and bacteria activities on the medicinal herbs\n\n1) The oil constituents from leaves and flowers of Agrimonia eupatoria L. were obtained using a hydro-distn. method in both cultivated and wild growing conditions in Iran.\u00a0 The oils were analyzed by capillary gas chromatog., using flame ionization and mass spectrometric detection.\u00a0 Both wild growing and cultivated leaves as well as wild growing and cultivated flower oils were found to contain 21, 21, 27 and 25 components resp.\u00a0 The major constituents in the wild growing leaf oil were b-caryophyllene, caryophyllene oxide, a-humulene and E-b-farnesene, and in the cultivated leaf oil were a-pinene, b-caryophyllene, E-a-farnesene and cumin aldehyde.\u00a0 The main constituents in the oil of the wild growing flowers were b-caryophyllene, E-b-farnesene and a-humulene and in the cultivated flowers were b-caryophyllene, caryophyllene oxide and a-copaene.\n\n2) The hepatoprotective activities of Agrimonia eupatoria L. ext. were assessed by measuring hematol. and serol. levels in SD rats following chem.-induced liver injury.\u00a0 The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) were dose-dependently decreased in carbon tetrachloride (CCl4) and D-galactosamine (GalN)\/lipopolysaccharide (LPS)-induced liver injury in rats.\u00a0 These results revealed significant, dose-dependent hepatoprotective potential for A. eupatoria ext. as it restored the majority of abnormal hepatic parameters in exptl. liver damage in rats; it may therefore be useful in recovery of liver disorders.\n\n"},{"@type":"Nota de alcance","@lang":"es","@value":"Patente extra\u00edda del Chemical Abstracts= Patent extrated from the Database Chemical Abstracts\n\u00a0\n\u00a0Pharmaceutical and Food Composition Comprising Agrimonia Extracts for Preventing or Treating Non-viral Hepatitis and Hepatic Disease.\u00a0\u00a0\u00a0\u00a0\u00a0 Lea, Young Sung; Ahn, Dong Ho; Zee, Ok Pyo; Kwak, Jong Hwan; Kang, Se Chan; Choi, Han; Kim, Man Bae; Lee, Min Kyung.\u00a0 (Bio Korea Co., Ltd., S. Korea).\u00a0\u00a0\u00a0 PCT Int. Appl.\u00a0 (2007),\u00a0\u00a0\u00a0\u00a0 CODEN: PIXXD2\u00a0 WO\u00a0 2007100206\u00a0 A1\u00a0 20070907\u00a0 Designated States W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US.\u00a0 Designated States RW: AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IS, IT, LU, MC, NL, PT, SE, TR, BF, BJ, CF, CG, CI, CM, GA, ML, MR, NE, SN, TD, TG.\u00a0 Patent\u00a0 written in English.\u00a0\u00a0\u00a0 Application: WO\u00a0 2007-KR1010\u00a0 20070227.\u00a0 Priority: KR\u00a0 2006-19471\u00a0 20060228.\u00a0 AN 2007:998828\u00a0\u00a0\u00a0 CAPLUS\u00a0\u00a0 (Copyright (C) 2011 ACS on SciFinder (R))\u00a0\u00a0 \n\nA pharmaceutical or food composition for preventing or treating non-viral hepatitis and hepatic disease comprises an extract of genus Agrimonia (also named Agrimonia, Jipsinnamul, Seonhakcho, Hwanghwacho and Talyukcho), selected from Agrimonia eupatoria L., Agrimonia pilosa L, Agrimonia coreana N., Agrimonia coreana N. for. pilosella Satake, Agrimonia gryposepala (A. gryposepala), Agrimonia rostellata (A. rostellata), Agrimonia pubescens (A. pubescens), Agrimonia parviflora (A. parviflora), Agrimonia striata (A. striata), Agrimonia ordorata (A. ordorata), Agrimonia incisa (A. incisa), Agrimonia polyphylla (A. polyphylla), Agrimonia microcarpa (A. microcarpa), Agrimonia bracteat (A. bracteat), Agrimonia repens (A. repens), Agrimonia platycarpa (A. platycarpa), Agrimonia pumila (A. pumila) and Agrimonia asiatica (A. asiatica), wherein the extract may be a water-soluble extract, an organic solvent-soluble extract, or a mixture thereof.\u00a0 The composition of genus Agrimonia has an effect of protecting hepatic cells; and it is useful for a functional food, a nutritional supplement, a nutrient, a pharmafood, a health food, a nutraceutical, a designer food and a food additive, for preventing or treating non-viral hepatitis and hepatic disease, which is chronic or acute hepatitis induced by a drug selected from methotrexate, tetracycline, isoniazid, nitrofurantoin, halothane, acetaminopen, aspirine, oxypenicillin and vitamin A."},{"@type":"Nota de alcance","@lang":"es","@value":"\n\nPARTE UTILIZADA= Used part: Sumidades floridas.\u00a0\n\n\nACCI\u00d3N FARMACOL\u00d3GICA= Pharmacological action: Antidiarreico, antiflamatoirio local y cicatrizante.\n\n\n\nPOSOLOG\u00cdA= Posology: Uso interno, dosis media diaria de 3 a 6 g de droga o la cantidad equivalente de sus preparaciones. Uso externo, compresas embebidas con una decocci\u00f3n al 10 % , var\u00edas veces al d\u00eda. \n\n\n\nCOMPOSICI\u00d3N QU\u00cdMICA= Chemical composition: Abundantes taninos cat\u00e9quicos y el\u00e1gicos. Acidos sil\u00edcico, asc\u00f2rbico y urs\u00f3lico. Flavonoides y trazas de aceite esencial.\u00a0\n\n\n\n\n\n\n\nZONA GEOGR\u00c1FICA= Geografical zone: Espa\u00f1a. \n\n---------\nDroga: las hojas y la sumidad florida.\n\nPropiedades:\nPor su abundancia en taninos tiene efectos astringente, cicatrizante, antidiarreico y\u00a0 hemost\u00e1tico local. Adem\u00e1s es antiinflamatorio.\n\n"},{"@type":"Nota de alcance","@lang":"en","@value":"Range. Mostly North Temperate Zone. In Myanmar, found in Mandalay. \n\nUses. Plant (part unspecified in Nordal 1963) used as diuretic and astringent. \n------------\nOrigin:\nThe Himalayas from Kashmir to West Bengal at 900-3000m, and in Arunachal Pradesh, Nagaland and Meghalaya.\n\nAction:\nAstringent, antiinflammatory, hepatic, cholagogue, diuretic, mild haemostatic, antibacterial. Used for irritations and infections of the intestinal tract, gallbladder diseases, hyperacidity, colic, urinary disorders (bedwetting, incontinence), sluggish liver, mucus membrane inflammations; externally for ulcerated and discharging skin, psoriasis and seborrhoic eczemas.\n\nToxicity:\nCoumarins interact with anticoagulants, and drugs that increase the\nrisk of bleeding Furanocoumarin content increase photosensitivity. (Sharon M. Herr.)\n\n"},{"@type":"Nota bibliogr\u00e1fica","@lang":"es","@value":"\n\n1) Fitoterapia : vademecum de prescripcion. 4\u00aa\u00a0 ed. Barcelona : Masson, 2003, p.93.\n\n2) NAVAEI, Mehrdokht Najafpour; MIRZA, Mehdi.\u00a0 A comparative study of the essential oils of Agrimonia eupatoria both cultivated and wild growing conditions in Iran. Journal of Essential Oil-Bearing Plants. 2009, vol.12, n\u00ba3, p.369-373. \n\u00a0\n3) KANG, Se Chan, et al. Protective effect of Agrimonia eupatoria L. against chemical-induced hepatotoxicity. BioChemistry: An Indian Journal. 2008, vol.2, n\u00ba1, p.8-11. \n4) ALONSO, Jorge R. Tratado de fitomedicina : bases cl\u00ednicas y farmacol\u00f3gicas. Buenos Aires : ISIS, 1998, p. 178. \n5) Linares Gimeno, Nuria\/ Plantas Medicinales: cuaderno de trabajo. UPA: Madrid, 2013. p . - 67\n6) DeFilipps, Robert A.; Krupnick, Gary A. \/ PhytoKeys, v. 102. - - p. 1 - 314,\u00a0 2018.\n7) Khare, C.P.\/ Indian Medicinal Plants. -- Nueva Dheli: Springer, 2007 . - p. 836.\n\n"}]}